Dom34 Rescues Ribosomes in 3′ Untranslated Regions

@article{Guydosh2014Dom34RR,
  title={Dom34 Rescues Ribosomes in 3′ Untranslated Regions},
  author={Nicholas R. Guydosh and Rachel Green},
  journal={Cell},
  year={2014},
  volume={156},
  pages={950-962}
}
Ribosomes that stall before completing peptide synthesis must be recycled and returned to the cytoplasmic pool. The protein Dom34 and cofactors Hbs1 and Rli1 can dissociate stalled ribosomes in vitro, but the identity of targets in the cell is unknown. Here, we extend ribosome profiling methodology to reveal a high-resolution molecular characterization of Dom34 function in vivo. Dom34 removes stalled ribosomes from truncated mRNAs, but, in contrast, does not generally dissociate ribosomes on… CONTINUE READING
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