Dolichol-dependent protein glycosylation in a deoxy-glucose-resistant baby-hamster-kidney cell line.


The formation in vivo of lipid-linked oligosaccharides is inhibited by deoxy-glucose in wild-type BHK cells but not in a cell-line (dGR) selected for resistance towards deoxyglucose. On the other hand, the formation in vitro of lipid-linked oligosaccharides by membranes from dGR (and wild-type) cells is inhibited by GDPdeoxyglucose, the main metabolite… (More)


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