Dolichol‐linked oligosaccharide and glycoprotein biosyntheses in glial cells in primary culture: Development and enzymatic correlates

  title={Dolichol‐linked oligosaccharide and glycoprotein biosyntheses in glial cells in primary culture: Development and enzymatic correlates},
  author={S Ishii and Joseph J. Volpe},
  journal={Journal of Neuroscience Research},
  • S. Ishii, J. Volpe
  • Published 1 August 1988
  • Biology, Medicine
  • Journal of Neuroscience Research
Primary cultures of cerebral glia derived from neonatal rat brain were utilized to determine (1) the developmental changes of dolichol‐linked oligosaccharide and N‐linked glycoprotein biosyntheses, (2) the enzymatic correlates of these developmental changes, and (3) the temporal relations between the biosyntheses of dolichol‐oligosaccharide and N‐linked glycoproteins and the biochemical expression of astrocytic and oligodendroglial differentiation. Marked, parallel developmental increases in… Expand
4 Citations
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  • M. Engle, J. Volpe
  • Biology, Medicine
  • Brain research. Developmental brain research
  • 1990
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The data suggest a temporally discrete period of activation of the dolichol-linked pathway to glycoprotein biosynthesis, whether the pathway is regulated coordinately or sequentially is a fertile topic for future study. Expand
Dolichol‐Linked Glycoprotein Synthesis in G1 Is Necessary for DNA Synthesis in Synchronized Primary Cultures of Cerebral Glia
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Enzymatic Regulation of Glycoprotein Synthesis in Peripheral Nervous System Myelin
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Postnatal changes in dolichol-pathway enzyme activities in cerebral cortex neurons.
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Glial differentiation in dissociated cell cultures of neonatal rat brain: Noncoordinate and density‐dependent regulation of oligodendroglial enzymes
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A developmental change in dolichyl phosphate mannose synthase activity in pig brain.
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Cholesterol Biosynthesis and Its Regulation in Dissociated Cell Cultures of Fetal Rat Brain: Developmental Changes and the Role of 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase
Primary cultures of cells dissociated from fetal rat brain were utilized to define the developmental changes in cholesterol biosynthesis and the role of HMG‐CoA reductase in the regulation of these changes, suggesting an intimate relationship of the sterol biosynthetic pathway with cellular proliferation and with oligodendroglial differentiation in developing mammalian brain. Expand
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