Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia

@inproceedings{Lyons2012Dok2MT,
  title={Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia},
  author={Anthony Q. Lyons and Eric J Downer and Derek A. Costello and Niamh Murphy and Marina A. Lynch},
  booktitle={Journal of Neuroinflammation},
  year={2012}
}
The interaction between the membrane glycoprotein, CD200 and its cognate receptor CD200 receptor (CD200R), has been shown to play a role in maintaining microglia in a quiescent state. There is evidence of increased activation under resting and stimulated conditions in microglia prepared from CD200-deficient mice compared with wild-type mice, whereas activation of the receptor by CD200 fusion protein (CD200Fc) ameliorates inflammatory changes which are evident in the central nervous system (CNS… CONTINUE READING
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