Dok-4 is a novel negative regulator of T cell activation.

@article{Grard2009Dok4IA,
  title={Dok-4 is a novel negative regulator of T cell activation.},
  author={Audrey G{\'e}rard and Marguerite Ghiotto and Camille Fos and Geoffrey Guittard and Daniel Compagno and Anne Galy and Serge Lemay and Daniel Olive and Jacques A Nun{\`e}s},
  journal={Journal of immunology},
  year={2009},
  volume={182 12},
  pages={
          7681-9
        }
}
  • Audrey Gérard, Marguerite Ghiotto, +6 authors Jacques A Nunès
  • Published in Journal of immunology 2009
  • Biology, Medicine
  • Dok-4 (downstream of tyrosine kinase-4) is a recently identified member of the Dok family of adaptor proteins, which are characterized by an amino-terminal pleckstrin homology domain, a phosphotyrosine-binding domain, and a carboxyl-terminal region containing several tyrosines and poly-proline-rich motifs. Two members of the Dok family, Dok-1 and Dok-2, have already been described as negative regulators in T cells. However, the function of Dok-4, which is also expressed in T cells, remains… CONTINUE READING

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