Doing it in reverse: 3'-to-5' polymerization by the Thg1 superfamily.

  title={Doing it in reverse: 3'-to-5' polymerization by the Thg1 superfamily.},
  author={Jane E. Jackman and Jonatha Gott and Michael W. Gray},
  volume={18 5},
The tRNA(His) guanylyltransferase (Thg1) family of enzymes comprises members from all three domains of life (Eucarya, Bacteria, Archaea). Although the initial activity associated with Thg1 enzymes was a single 3'-to-5' nucleotide addition reaction that specifies tRNA(His) identity in eukaryotes, the discovery of a generalized base pair-dependent 3'-to-5' polymerase reaction greatly expanded the scope of Thg1 family-catalyzed reactions to include tRNA repair and editing activities in bacteria… CONTINUE READING
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