Dogmas and surprises about the renin-angiotensin system and sodium reabsorption.

@article{Braam2006DogmasAS,
  title={Dogmas and surprises about the renin-angiotensin system and sodium reabsorption.},
  author={Branko Braam and Hein A. Koomans},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2006},
  volume={21 11},
  pages={
          3048-51
        }
}
After many years of studies on the renin–angiotensin system (RAS), one of the central concepts is that the RAS forms an effective defence mechanism against low-sodium states and hypotension. Low-perfusion pressure sensed by the afferent arteriole, low-distal delivery sensed by the macula densa and low blood pressure sensed by the sympathetic nervous system increase renin release, leading to angiotensin generation and sodium retention, vasoconstriction and restoration of blood pressure. About 15… CONTINUE READING

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