Dog vaccination with EgM proteins against Echinococcus granulosus

@article{Zhang2018DogVW,
  title={Dog vaccination with EgM proteins against Echinococcus granulosus},
  author={Zhuang-Zhi Zhang and Gang Guo and Jun Li and Baoxin Shi and Li Zhao and Baoping Guo and Xu Zhang and Jun-Wei Wang and Xueting Zheng and Wenjing Qi and Li He and Wenbao Zhang},
  journal={Infectious Diseases of Poverty},
  year={2018},
  volume={7}
}
BackgroundDogs play a pivotal role in the transmission of cystic echinococcosis (CE), a zoonosis caused by the tapeworm Echinococcus granulosus. We showed previously that dogs vaccinated with two E. granulosus adult-worm specific proteins, EgM9 and EgM123, emulsified with Freund’s adjuvants induced significant protective efficacy in terms of reduction in worm burden and egg production after 45 days post-infection. It was not known whether this protection can be sustained using adjuvants… 
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References

SHOWING 1-6 OF 6 REFERENCES
Vaccination of dogs against Echinococcus granulosus, the cause of cystic hydatid disease in humans.
TLDR
It is shown that vaccination of the dog host against E. granulosus is feasible when recombinant proteins are used and successful suppression of egg development by vaccination would halt transmission to intermediate hosts, thereby effecting long-term control.
A Pilot Study for Control of Hyperendemic Cystic Hydatid Disease in China
TLDR
Monthly treatment of dogs with PZQ and culling unwanted and stray dogs have been shown to be an efficient, highly cost-effective and practicable measure for implementation in rural communities and the Chinese Ministry of Health has launched an extensive CHD control program using this control strategy.
Diagnosis, treatment, and management of echinococcosis
TLDR
Echinococcosis (hydatid disease) is caused by the larvae of dog and fox tapeworms of the genus Echinococcus of the family Taeniidae, characterised by long term growth of metacestode (Hydatid) cysts in humans and mammalian intermediate hosts.
A gene family from Echinococcus granulosus differentially expressed in mature adult worms.