Dog star rising: the canine genetic system

  title={Dog star rising: the canine genetic system},
  author={Nathan B. Sutter and Elaine A. Ostrander},
  journal={Nature Reviews Genetics},
Purebred dogs are providing invaluable information about morphology, behaviour and complex diseases, both of themselves and humans, by supplying tractable populations in which to map genes that control those processes. The diversification of dog breeds has led to the development of breeds enriched for particular genetic disorders, the mapping and cloning of which have been facilitated by the availability of the canine genome map and sequence. These tools have aided our understanding of canine… 

Human Genetics and the Canine System

This chapter discusses the history of canine genomics along with recent advances in resource development to highlight the utility of the canine system for mapping traits and finding mutations important in both human and companion animal science.

Canine Genomics and Genetics: Running with the Pack

This review discusses the advances in mapping and sequencing that accelerated the field in recent years, then highlights findings of interest related to disease gene mapping and population structure, and summarizes novel results on the genetics of morphologic variation.

The dog: A powerful model for studying genotype-phenotype relationships.

  • F. GalibertC. André
  • Biology
    Comparative biochemistry and physiology. Part D, Genomics & proteomics
  • 2008

Lessons learned from the dog genome.

The dog genome.

Here, the main results obtained during the last ten years are reported, culminating in the recent publication of a complete dog genome sequence.

Comparing the Human and Canine Genomes

The dog is a very useful model to study human hereditary diseases and their therapy, including gene therapy, and knowledge on the human and dog genomes is very advanced.

The canine era: the rise of a biomedical model.

The increasing amount of whole-genome sequence data warrants better functional annotation of the canine genome to more effectively utilise this unique model to understand genetic contributions in morphological, behavioural and other complex traits.

The legacy of domestication: accumulation of deleterious mutations in the dog genome.

It is suggested that the majority of nonsynonymous alleles found in dogs are slightly deleterious and that two main factors may have contributed to their increase, a relaxation of selective constraint due to a population bottleneck and altered breeding patterns accompanying domestication.

Homozygosity mapping and sequencing identify two genes that might contribute to pointing behavior in hunting dogs

It is proposed that, together with other genetic, training and/or environmental factors, the nucleotide and associated amino acid variations identified in genes SETDB2 and CYSLTR2 contribute to pointing behavior.

Genome sequence, comparative analysis and haplotype structure of the domestic dog

A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes.



The domestic dog genome

An integrated linkage-radiation hybrid map of the canine genome

This work describes the integration of an expanded canine radiation hybrid map, comprised of 600 markers, with the latest linkage map of 341 markers, to generate a map of 724 markers, the densest map of the canine genome described to date.

Unleashing the canine genome.

The modern dog offers key advantages over other animal systems for mapping genes relevant to human disease and the strong promise of linkagedisequilibrium (LD) mapping in dogs is focused on.

Anchoring of canine linkage groups with chromosome-specific markers

An updated version of the canine linkage map is reported on, which includes 341 mapped markers distributed over the X and 37 autosomal linkage groups and is of sufficient density and characterization to initiate mapping of traits of interest.

A 1-Mb resolution radiation hybrid map of the canine genome

This work presents a comprehensive radiation hybrid map of the canine genome composed of 3,270 markers including 1,596 microsatellite-based markers, 900 cloned gene sequences and ESTs, 668 canine-specific bacterial artificial chromosome ends, and 106 sequence-tagged sites.

Extensive and breed-specific linkage disequilibrium in Canis familiaris.

Low haplotype diversity within regions of high LD, with 80% of chromosomes in a breed carrying two to four haplotypes, as well as a high degree of haplotype sharing among breeds, are reported.

Genetic Evidence for an East Asian Origin of Domestic Dogs

A larger genetic variation in East Asia than in other regions and the pattern of phylogeographic variation suggest an East Asian origin for the domestic dog, ∼15,000 years ago.

Multiple and ancient origins of the domestic dog.

Sequences from both dogs and wolves showed considerable diversity and supported the hypothesis that wolves were the ancestors of dogs, suggesting that dogs originated more than 100,000 years before the present.

A whole-genome radiation hybrid map of the dog genome.

A whole genome radiation hybrid map of the canine genome was constructed by typing 400 markers, including 218 genes and 182 microsatellites, on a panel of 126 radiation hybrid cell lines, and should prove a powerful tool for localizing and identifiying genes implicated in pathological and phenotypical traits.

A linkage map of the canine genome.

A genetic linkage map of the canine genome has been developed by typing 150 microsatellite markers using 17 three-generation pedigrees, composed of 163 F2 individuals, to serve as a foundation for development of a comprehensive canine genetic map.