Dog models of naturally occurring cancer.

  title={Dog models of naturally occurring cancer.},
  author={Jennie L. Rowell and Donna O. McCarthy and Carlos E. Alvarez},
  journal={Trends in molecular medicine},
  volume={17 7},
Studies using dogs provide an ideal solution to the gap in animal models for natural disease and translational medicine. This is evidenced by approximately 400 inherited disorders being characterized in domesticated dogs, most of which are relevant to humans. There are several hundred isolated populations of dogs (breeds) and each has a vastly reduced genetic variation compared with humans; this simplifies disease mapping and pharmacogenomics. Dogs age five- to eight-fold faster than do humans… CONTINUE READING

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