Dog mastocytoma cells produce transforming growth factor beta 1.

  title={Dog mastocytoma cells produce transforming growth factor beta 1.},
  author={Donna W Pennington and Ana Rodriguez Lopez and Paul Thomas and Chris Peck and Warren M. Gold},
  journal={The Journal of clinical investigation},
  volume={90 1},
Transforming growth factor-beta (TGF beta) promotes deposition of extracellular matrix and is associated with fibrotic conditions both in experimental animals and in humans. Although a role for mast cells has been suspected in the pathogenesis of fibrosis, no potent mediator capable of stimulating fibroblast growth or extracellular matrix deposition has been identified in mast cell supernatants. We report here the constitutive production of TGF beta 1 by four dog mastocytoma cell lines. TGF… CONTINUE READING

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