Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group.

@article{TorpPedersen1999DofetilideIP,
  title={Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group.},
  author={Christian Torp-Pedersen and Mogens M\oller and Poul Erik Bloch-Thomsen and Lars Valeur K\ober and E Sand\oe and Kenneth Egstrup and Erik Agner and Jan E Carlsen and J\orgen Videbaek and Bradley Marchant and A. John Camm},
  journal={The New England journal of medicine},
  year={1999},
  volume={341 12},
  pages={857-65}
}
BACKGROUND Atrial fibrillation occurs frequently in patients with congestive heart failure and commonly results in clinical deterioration and hospitalization. Sinus rhythm may be maintained with antiarrhythmic drugs, but some of these drugs increase the risk of death. METHODS We studied 1518 patients with symptomatic congestive heart failure and severe left ventricular dysfunction at 34 Danish hospitals. We randomly assigned 762 patients to receive dofetilide, a novel class III antiarrhythmic… CONTINUE READING
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