Dofetilide: a new class III antiarrhythmic agent

  title={Dofetilide: a new class III antiarrhythmic agent},
  author={H. Roukoz and W. Saliba},
  journal={Expert Review of Cardiovascular Therapy},
  pages={19 - 9}
  • H. Roukoz, W. Saliba
  • Published 2007
  • Medicine
  • Expert Review of Cardiovascular Therapy
  • Dofetilide is a relatively new class III antiarrhythmic agent that selectively blocks the rapid component of the cardiac ion channel delayed rectifier current. This results in an increase in the action potential duration and effective refractory period of the myocyte, thereby terminating reentrant tachyarrhythmias and preventing their re-induction. Oral dofetilide is effective in the conversion of atrial fibrillation and flutter to sinus rhythm and in the maintenance of sinus rhythm after… CONTINUE READING
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