Dofetilide, a New Class III Antiarrhythmic Agent

@article{Lenz2000DofetilideAN,
  title={Dofetilide, a New Class III Antiarrhythmic Agent},
  author={Thomas L. Lenz and Daniel E. Hilleman},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2000},
  volume={20}
}
  • T. L. Lenz, D. Hilleman
  • Published 1 July 2000
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Dofetilide is a new antiarrhythmic agent recently approved for conversion and maintenance of sinus rhythm in patients with atrial fibrillation (AF) and atrial flutter (AFl). It is a class III antiarrhythmic that works by selectively blocking the rapid component of the delayed rectifier outward potassium current. Dofetilide prolongs the effective refractory period in accessory pathways, both anterograde and retrograde. This can be seen on the electrocardiogram through a dose‐dependent… 
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TLDR
Pharmacodynamic data demonstrate dose- and concentration-dependent effects on myocardial repolarization as evidenced by prolongations of the QTC interval, supporting the contention that dofetilide is a highly selective class III antiarrhythmic agent.
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