Does vitamin D supplementation alleviate chronic nonspecific musculoskeletal pain? A systematic review and meta-analysis

  title={Does vitamin D supplementation alleviate chronic nonspecific musculoskeletal pain? A systematic review and meta-analysis},
  author={Manasi Gaikwad and Simon J Vanlint and M. Mittinity and G. Lorimer Moseley and Nigel P. Stocks},
  journal={Clinical Rheumatology},
Chronic nonspecific musculoskeletal pain (CNMP) is an idiopathic condition often seen in general practice and rheumatology clinics, the aetiology of which may include vitamin D deficiency. The objective of the present study is to evaluate the effectiveness of vitamin D supplementation in the management of CNMP through a systematic review and meta-analysis. According to PRISMA guidelines, PubMed, Embase, Web of Science, Cochrane and Scopus electronic databases were searched for randomised… 

The role of vitamin D testing and replacement in fibromyalgia: a systematic literature review

A systematic literature review of clinical studies and randomized controlled trials published in English during January 2000 to June 2017 found an association between vitamin D deficiency and fibromyalgia, but no clear consensus was obtained on the effect of vitamin D on pain or symptom control.

The Effect of Vitamin D Supplementation on Treatment-Induced Pain in Cancer Patients: A Systematic Review.

Effect of supplementation of vitamin D and calcium on patients suffering from chronic non-specific musculoskeletal pain: A pre-post study

Serum vitamin D, serum calcium, and physical activity levels increased, whereas pain, weight, BMI, and WHR decreased significantly post-intervention, which significantly decreases chronic non-specific musculoskeletal pain.

The effect of vitamin D supplementation on pain, quality of life, and nerve conduction studies in women with chronic widespread pain

Vitamin D supplementation therapy decreased pain and increased quality of life without significantly affecting nerve conduction in patients with CWP.

The Role of Vitamin D in Primary Headache–from Potential Mechanism to Treatment

Overall, there is not enough evidence to recommend vitamin D supplementation to all headache patients, but the current literature indicates that it may be beneficial in some patients suffering headaches, mainly migraineurs, to reduce the frequency of headaches, especially in those with vitamin D deficiency.

Monthly vitamin D supplementation, pain, and pattern of analgesic prescription: secondary analysis from the randomized, double-blind, placebo-controlled Vitamin D Assessment study

Long-term monthly high-dose vitamin D supplementation did not improve mean PIQ-6 score or reduce analgesic dispensing in the general population, and focusing on vitamin D deficient participants, there was a lower risk of dispensing nonsteroidal anti-inflammatory drugs in the vitamin D group compared with placebo.

Phenome wide association study of vitamin D genetic variants in the UK Biobank cohort

The aim of the PhD was to comprehensively explore the association between vitamin D and multiple outcomes and to update the vitamin D umbrella review published in 2015, by summarizing the evidence from meta-analyses of observational studies and meta-Analyses of RCTs published between 2014 and 2018.



Vitamin D for the treatment of chronic painful conditions in adults.

There was no consistent pattern that vitamin D treatment was associated with greater efficacy than placebo in any chronic painful condition, and a large beneficial effect of vitamin D across different chronic painful conditions is unlikely.

Is Vitamin D Deficiency associated with Non Specific Musculoskeletal Pain?

Treatment with vitamin D can relieve the pain in majority of the patients withitamin D deficiency and Lack of response can be due to insufficient increase in serum vitamin D concentration.

Vitamin D Supplementation for Nonspecific Musculoskeletal Pain in Non-Western Immigrants: A Randomized Controlled Trial

There is a small positive effect 6 weeks after high-dose vitamin D3 on persistent nonspecific musculoskeletal pain, and future research should focus on longer follow-up, higher supplementation doses, and mental health.

Vitamin D supplement as an adjuvant in the management of chronic musculoskeletal pain

Two cases of improvement/ resolution of chronic pain after vitamin D repletion in a pain practice setting in Lahore are reviewed, finding that in some cases, it may result in complete resolution of symptoms.

Diffuse Musculoskeletal Pain Is Not Associated With Low Vitamin D Levels or Improved by Treatment With Vitamin D

  • A. WarnerSarah A Arnspiger
  • Medicine
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
  • 2008
Low vitamin D levels are not associated with diffuse musculoskeletal pain, and treatment with vitamin D does not reduce pain in patients with diffuse pain who have lowitamin D levels.

Vitamin D status in patients with musculoskeletal pain, fatigue and headache: A cross-sectional descriptive study in a multi-ethnic general practice in Norway

A high prevalence of hypovitaminosis D is shown in patients with non-specific musculoskeletal pain, headache, or fatigue for whom the GP had suspected a low vitamin D level, and these results indicate that GPs should maintain awareness ofHypov vitamin D levels and refer patients who report headaches, fatigue, and musculo- skeletal pain with minimal sun exposure and a low dietary vitamin D intake for assessment.

Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain.

All patients with persistent, nonspecific musculoskeletal pain are at high risk for the consequences of unrecognized and untreated severe hypovitaminosis D.

The effect of oral and parenteral vitamin D supplementation in the elderly: a prospective, double-blinded, randomized, placebo-controlled study

The megadose vitamin D administration increases quality of life, decreases pain, and improves functional mobility via po or im route in the elderly.