Does vitamin C act as a pro‐oxidant under physiological conditions?

@article{Carr1999DoesVC,
  title={Does vitamin C act as a pro‐oxidant under physiological conditions?},
  author={Anitra C. Carr and Balz Frei},
  journal={The FASEB Journal},
  year={1999},
  volume={13},
  pages={1007 - 1024}
}
Vitamin C readily scavenges reactive oxygen and nitrogen species and may thereby prevent oxidative damage to important biological macromolecules such as DNA, lipids, and proteins. [...] Key Method To examine this issue, we reviewed studies that investigated the role of vitamin C, both in the presence and absence of metal ions, in oxidative DNA, lipid, and protein damage. We found compelling evidence for antioxidant protection of lipids by vitamin C in biological fluids, animals, and humans, both with and…Expand
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Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone
TLDR
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This Review Article is focused on the action of the reactive oxygenated species in inducing oxidative injury of the lipid membrane components, as well as on the ability of antioxidants (of differentExpand
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Oxygen reactive free radicals, more known as reactive oxygen species (ROS) have dual nature. On the one hand, they necessary for normal function of the cell, but on the other side when ROS is inExpand
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Molecular and biological mechanisms of antioxidant action
  • B. Frei
  • Medicine, Biology
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1999
TLDR
This conference presented a contemporary view of the mechanisms of oxidative damage to lipids, proteins, and DNA and the molecular, biochemical, and physiological action of antioxidants and their role in cell biology, with a focus on small molecule antioxidants. Expand
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TLDR
It is demonstrated that in iron-overloaded plasma, AA acts an antioxidant toward lipids, and the hypothesis that the combination of high plasma concentrations of AA and BDI, or BDI alone, causes oxidative damage to lipids and proteins in vivo is not supported. Expand
Novel repair action of vitamin C upon in vivo oxidative DNA damage
TLDR
The kinetics of 8‐oxo‐2′‐deoxyguanosine removal and processing in vivo are illustrated, for the first time in humans, suggesting a role for vitamin C in the regulation of DNA repair enzymes and thereby demonstrating a non‐scavenging antioxidant effect. Expand
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TLDR
The results show that vitamin C can either aggravate or alleviate the oxidative tissue damage depending on the presence of metal ions released from damaged cells. Expand
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TLDR
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TLDR
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TLDR
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TLDR
Vitamin C did not alter LDL oxidation but it may have a protective role against lipid peroxidation as shown by decreased plasma MDA levels and enhanced vitamin E and GSH status. Expand
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TLDR
The results suggest a protective role of antioxidant vitamins and significant individual variability in response in response to vitamin supplementation. Expand
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TLDR
Proteins are also key targets in defensive cytolysis and in inflammatory self-damage, and the possibility of selective protection against protein oxidation (antioxidation) is raised. Expand
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