Does vitamin C act as a pro‐oxidant under physiological conditions?

@article{Carr1999DoesVC,
  title={Does vitamin C act as a pro‐oxidant under physiological conditions?},
  author={Anitra C. Carr and Balz Frei},
  journal={The FASEB Journal},
  year={1999},
  volume={13},
  pages={1007 - 1024}
}
Vitamin C readily scavenges reactive oxygen and nitrogen species and may thereby prevent oxidative damage to important biological macromolecules such as DNA, lipids, and proteins. [...] Key Method To examine this issue, we reviewed studies that investigated the role of vitamin C, both in the presence and absence of metal ions, in oxidative DNA, lipid, and protein damage. We found compelling evidence for antioxidant protection of lipids by vitamin C in biological fluids, animals, and humans, both with and…Expand
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Dual role of vitamin C in an oxygen-sensitive system: Discrepancy between DNA damage and dell death
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In the presence of vitamin C, the 8-hydroxydeoxyguanosine (8OHdG) formation induced by oxygen exposure was enhanced, probably due to the action of Vitamin C on hydrogen peroxide generated during oxygen exposure. Expand
Vitamin C: An Antioxidant Agent
Vitamin C or ascorbic acid (AsA) is a naturally occurring organic compound with antioxidant properties, found in both animals and plants. It functions as a redox buffer which can reduce, and thereby… Expand
Metal Ions Mediated Pro-Oxidative Reactions with Vitamin C: Possible Implications for Treatment of Different Malignancies
Vitamin C is an acidic molecule with strong reducing activity. It is an essential micronutrient in man, due to the absence of L-gulonolactone oxidase. Vitamin C has several important roles and there… Expand
Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone
TLDR
Investigation of the antioxidant/pro-oxidant effects of ascorbic acid in reactions involving iron and the iron chelator deferiprone suggests that despite a much lower stability constant of the iron–ascorbate complex compared to the FeL13 complex, ascorBic acid at high concentrations is able to substitute L1 in theFeL13 chelate complex resulting in the formation of mixed L12AscFe complex. Expand
Vitamin C suppresses oxidative lipid damage in vivo, even in the presence of iron overload.
TLDR
Data indicate that 1) ascorbate acts as an antioxidant toward lipids in vivo, even in the presence of iron overload; 2) iron loading per se does not cause oxidative lipid damage but is associated with growth retardation and tissue damage, both of which are not affected by vitamin C; and 3) the combination of iron loading with a low ascorBate status causes additional pathophysiological changes, in particular, increased plasma triglycerides. Expand
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
TLDR
Dose concentration studies of vitamin C in healthy people showed a sigmoidal relationship between oral dose and plasma and tissue vitamin C concentrations, so optimal dosing is critical to intervention studies using vitamin C. Expand
The role of antioxidants in the chemistry of oxidative stress: A review.
This Review Article is focused on the action of the reactive oxygenated species in inducing oxidative injury of the lipid membrane components, as well as on the ability of antioxidants (of different… Expand
REACTIVE OXYGEN SPECIES AND THEIR RELATION TO CARCINOGENESIS
Oxygen reactive free radicals, more known as reactive oxygen species (ROS) have dual nature. On the one hand, they necessary for normal function of the cell, but on the other side when ROS is in… Expand
An Overview of the Characteristics and Function of Vitamin C in Various Tissues: Relying on its Antioxidant Function
TLDR
The wide role of ascorbate, a neuromodulator of glutamatergic and dopaminergic system and related behaviors, also improves components of the immune system. Expand
Molecular and biological mechanisms of antioxidant action
  • B. Frei
  • Medicine, Biology
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1999
TLDR
This conference presented a contemporary view of the mechanisms of oxidative damage to lipids, proteins, and DNA and the molecular, biochemical, and physiological action of antioxidants and their role in cell biology, with a focus on small molecule antioxidants. Expand
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References

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TLDR
It is demonstrated that in iron-overloaded plasma, AA acts an antioxidant toward lipids, and the hypothesis that the combination of high plasma concentrations of AA and BDI, or BDI alone, causes oxidative damage to lipids and proteins in vivo is not supported. Expand
Novel repair action of vitamin C upon in vivo oxidative DNA damage
TLDR
The kinetics of 8‐oxo‐2′‐deoxyguanosine removal and processing in vivo are illustrated, for the first time in humans, suggesting a role for vitamin C in the regulation of DNA repair enzymes and thereby demonstrating a non‐scavenging antioxidant effect. Expand
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TLDR
The results show that vitamin C can either aggravate or alleviate the oxidative tissue damage depending on the presence of metal ions released from damaged cells. Expand
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TLDR
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TLDR
It is found that low micromolar concentrations of both AA and DHA protect LDL against oxidation induced by Cu2+ or by hemin and hydrogen peroxide, and AA can terminate lipid peroxidation, thereby protecting partially oxidized LDL against further oxidative modification. Expand
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TLDR
Dietary vitamin C protects against endotoxin-induced oxidative damage to proteins in the guinea pig liver, mainly due to a direct protective effect of the increased hepatic ascorbate levels present in vitamin C-supplemented animals. Expand
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TLDR
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TLDR
Vitamin C did not alter LDL oxidation but it may have a protective role against lipid peroxidation as shown by decreased plasma MDA levels and enhanced vitamin E and GSH status. Expand
Dietary supplementation with vitamins C and E inhibits in vitro oxidation of lipoproteins.
TLDR
The results suggest a protective role of antioxidant vitamins and significant individual variability in response in response to vitamin supplementation. Expand
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TLDR
Proteins are also key targets in defensive cytolysis and in inflammatory self-damage, and the possibility of selective protection against protein oxidation (antioxidation) is raised. Expand
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