Does treatment of vulvar lichen sclerosus influence its prognosis?

@article{Cooper2004DoesTO,
  title={Does treatment of vulvar lichen sclerosus influence its prognosis?},
  author={Susan M. Cooper and X-H Gao and Jennifer Powell and Fenella T. Wojnarowska},
  journal={Archives of dermatology},
  year={2004},
  volume={140 6},
  pages={
          702-6
        }
}
OBJECTIVE To record the clinical features, symptomatic response to topical steroids, and resolution of clinical signs in a large cohort of female patients with vulvar lichen sclerosus. DESIGN Descriptive cohort study with a mean follow-up of 66 months. SETTING The vulvar clinics of a teaching hospital and of a district general hospital in Oxfordshire, England. PATIENTS Three hundred twenty-seven patients (74 girls and 253 women) with a definite clinical diagnosis of vulvar lichen… 
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TLDR
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TLDR
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TLDR
Patients should be aware that LS may improve symptomatically but usually does not entirely resolve at puberty and that the disease in women may be associated with development of vulvar SCC.
Childhood vulvar lichen sclerosus: an increasingly common problem.
TLDR
Although the cause of LS remains uncertain, it is not a rare disease in prepubertal girls and current optimal management includes prompt diagnosis and institution of treatment with a potent topical steroid.
Lichen sclerosus of the vulva. Long-term steroid maintenance therapy.
TLDR
The graduated topical steroid regimen has a high response rate and takes a relatively short time to achieve, justifying the use of graduated topical steroids for this condition.
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TLDR
A 6- to 8-week course of ultrapotent topical corticosteroid is a safe and effective treatment for genital lichen sclerosus in pediatric patients.
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TLDR
Data support the view that LS is a precursor of SCC, although characterized by slight tendency to evolve to carcinoma, and medical treatment of LS, although useful in the control of severity of disease, did not seem to be able to prevent the evolution to malignancy.
Treatment of Childhood Vulvar Lichen Sclerosus with Potent Topical Corticosteroid
TLDR
It is concluded that in children, as in adults, potent topical corticosteroid is a safe and effective treatment for vulvar lichen sclerosus.
Clinical and histologic effects of topical treatments of vulval lichen sclerosus. A critical evaluation.
TLDR
Clobetasol propionate (.05%) (a very potent topical steroid) is the therapy of choice in vulval lichen sclerosus and a significant reduction in epidermal atrophy is observed after treatment.
Successful treatment of vulvar lichen sclerosus with topical tacrolimus.
TLDR
Clinical examination showed well-demarcated, smooth, whitish shiny plaques that affected the labia minora, introitus vaginae, and the clitoral hood that extended to the posterior fourchette, perineum, and anus and suggested a diagnosis of lichen sclerosus.
The treatment of vulval lichen sclerosus with a very potent topical steroid (clobetasol Propionate 0.05%) cream
TLDR
The clinical and histological response to 12 weeks of treatment with a very potent topical fluorinated steroid was studied in patients with vulval lichen sclerosus and showed a significant reduction in the characteristic features of LS.
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TLDR
Clobetasol propionate cream is recommended for treatment of lichen sclerosus, with a 77% chance of complete remission of symptoms and a 47% chances of improvement in the clinical appearance of the vulva.
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