Does treatment delay in first-episode psychosis really matter?

@article{Harrigan2000DoesTD,
  title={Does treatment delay in first-episode psychosis really matter?},
  author={Susy Harrigan and Patrick D. McGorry and Helen Krstev},
  journal={Schizophrenia Research},
  year={2000},
  volume={41}
}
Background. Relatively few predictors of outcome in first-episode psychosis are potentially malleable and duration of untreated psychosis (DUP) is one. However, the degree to which DUP is mediated by other predictors of outcome is unclear. This study examines the specific effects of DUP on 12-month outcome after adjusting for effects of potential confounders and moderating variables. Method. The sample comprised 354 first-episode psychosis patients followed up 12-months after remission… 
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TLDR
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The findings suggest that five years of specialized early intervention was most beneficial when the total duration from symptom start to treatment was shorter than 6 months, and highlight the importance of avoiding delays within the mental health service provision.
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TLDR
The findings underline the importance of taking account of the phenomenological overlap between measures of negative symptoms and social function when investigating the effects of DUP.
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TLDR
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TLDR
Supporting evidence is provided that delayed treatment to first-episode psychosis is associated with poorer cognitive and clinical outcomes and that DUP may specifically affect memory function and its adverse impact on verbal memory may only become evident at a later stage of the recovery process.
follow-up study of first-episode schizophrenia Duration of untreated psychosis and social function: 1-year
TLDR
It is revealed that longer DUP significantly predicted more severe positive and negative symptoms and poorer social function at 1 year, independent of scores at presentation, underline the importance of taking account of the phenomenological overlap between measures.
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TLDR
Shorter DUP and good premorbid function each independently are associated with better clinical response, including improvement in overall psychopathology and negative symptoms, and earlier antipsychotic treatment isassociated with better outcomes in first-episode schizophrenia.
Outcome measures in early psychosis
  • S. Singh
  • Medicine, Psychology
    British Journal of Psychiatry
  • 2007
TLDR
The evolution of the concept of DUP is explored, the evidence for its predictive value is synthesised, the problems in measurement are highlighted, and the potential pitfalls are considered.
Factors contributing to the duration of untreated psychosis
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