Does the sliding dichotomy result in higher powered clinical trials for stroke and traumatic brain injury research?

@article{Price2013DoesTS,
  title={Does the sliding dichotomy result in higher powered clinical trials for stroke and traumatic brain injury research?},
  author={Megan Price and Vicki Hertzberg and David D. Wright},
  journal={Clinical trials},
  year={2013},
  volume={10 6},
  pages={924-34}
}
BACKGROUND Recent research has proposed a new method for defining a favorable outcome in traumatic brain injury and stroke research. PURPOSE This new method is called the sliding dichotomy, and it is suggested as a potential solution to the problem of underpowered clinical trials. METHODS We present a brief simulation study and graphical comparison of the power of each method to detect varying treatment effect sizes. RESULTS Simulations of a patient population similar to the National… CONTINUE READING