Does the release of arachidonic acid from cells play a role in cancer chemoprevention?

@article{Levine2003DoesTR,
  title={Does the release of arachidonic acid from cells play a role in cancer chemoprevention?},
  author={L. Levine},
  journal={The FASEB Journal},
  year={2003},
  volume={17},
  pages={800 - 802}
}
  • L. Levine
  • Published 2003
  • Biology, Medicine
  • The FASEB Journal
COX‐2 is overexpressed in cancer cells and has become a major target for cancer preventive drugs. NSAIDs, retinoids, antioxidants, and PPAR agonists, reported to be chemopreventive, suppress COX‐2 synthesis. NSAIDs also have been shown to be chemopreventive independent of COX‐2 activity. Common to all of these compounds is their ability to release arachidonic acid (AA) from rat liver cells in culture. Most of these compounds inhibit induced PGI2 production. Vitamin D3 and tamoxifen, however… Expand
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