Does the p75 neurotrophin receptor mediate Aβ‐induced toxicity in Alzheimer's disease?

  title={Does the p75 neurotrophin receptor mediate A$\beta$‐induced toxicity in Alzheimer's disease?},
  author={Elizabeth J. Coulson},
  journal={Journal of Neurochemistry},
  • E. Coulson
  • Published 1 August 2006
  • Biology
  • Journal of Neurochemistry
Alzheimer's disease is characterized by the over‐production and accumulation of amyloidogenic Aβ peptide, which can induce cell death in vitro. It has been suggested that the death signal could be transduced by the pan neurotrophin receptor (p75NTR). p75NTR is well known for its ability to mediate neuronal death in neurodegenerative conditions and is inextricably linked with changes that occur in Alzheimer's disease. Moreover, Aβ binds to p75NTR, activating signalling cascades. However, the… 

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