Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis?

@article{Hofstetter2005DoesTF,
  title={Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis?},
  author={Harald H. Hofstetter and Oleg S. Targoni and Alexey Y. Karulin and Thomas G. Forsthuber and Magdalena Tary-Lehmann and Paul Viktor Lehmann},
  journal={Journal of immunology},
  year={2005},
  volume={174 8},
  pages={4598-605}
}
In humans, studies of autoreactive T cells that mediate multiple sclerosis have been largely confined to testing peripheral blood lymphocytes. Little is known how such measurements reflect the disease-mediating autoreactive T cells in the CNS. This information is also not available for murine experimental allergic encephalomyelitis (EAE); the low number of T cells that can be obtained from the blood or the brain of mice prevented such comparisons. We used single-cell resolution IFN-gamma… CONTINUE READING

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