Does the fetal genotype affect maternal physiology during pregnancy?

Abstract

Conventional wisdom states that associations between fetal growth and diseases in pregnancy, such as pregnancy-induced hypertension (PIH) and gestational diabetes (GDM), result from effects of the mother's genotype or environment acting on her physiology which subsequently affect the fetus. However, recent evidence from human mothers carrying macrosomic offspring with Beckwith Wiedemann syndrome and pregnant mice carrying p57(kip2)-null offspring suggest that variation in the fetal genome can modify maternal physiology to increase fetal nutrient delivery and optimise growth. These are some of the first documented examples of such effects, whereby the genome of one individual directly affects the physiology of another related individual from the same species. We propose that this mechanism is involved in the aetiology of PIH and GDM.

01002002008200920102011201220132014201520162017
Citations per Year

446 Citations

Semantic Scholar estimates that this publication has 446 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Petry2007DoesTF, title={Does the fetal genotype affect maternal physiology during pregnancy?}, author={Clive J Petry and Ken K Ong and David B Dunger}, journal={Trends in molecular medicine}, year={2007}, volume={13 10}, pages={414-21} }