PURPOSE To investigate the influence of framework materials with different elasticity moduli on the biomechanical performance of fixed partial dentures (FPDs). MATERIALS AND METHODS A tooth-anchored three-unit FPD and surrounding tissues were modeled in two variants (veneered/full anatomical FPD) and loaded on the central unit. Three different framework materials (titanium, zirconia, high-performance polymer) were simulated. RESULTS The polymer framework resulted in reduced framework stresses and increased veneering stresses. Varying the framework material had minimal influence on the loading of surrounding tissue. CONCLUSIONS Using soft, novel materials as framework for dental FPDs does not negatively influence biomechanical loading of the involved biologic structures.