Does the Clearance of Inhaled (99m)Tc-Sestamibi Correlate with Multidrug Resistance Protein 1 Expression in the Human Lung?

@article{Mohan2016DoesTC,
  title={Does the Clearance of Inhaled (99m)Tc-Sestamibi Correlate with Multidrug Resistance Protein 1 Expression in the Human Lung?},
  author={Hosahalli Krishnamurthy Mohan and Thomas Routledge and Paul Cane and Lefteris Livieratos and James R. Ballinger and A Michael Peters},
  journal={Radiology},
  year={2016},
  volume={280 3},
  pages={924-30}
}
Purpose To examine the relation between the lung elimination rate of inhaled technetium 99m ((99m)Tc)-sestamibi and immunohistochemical expression of bronchopulmonary multidrug resistance protein 1 (MRP1) and permeability glycoprotein (P-gp) and assess the repeatability of the inhaled (99m)Tc-sestamibi clearance technique. Materials and Methods (99m)Tc-sestamibi is a known substrate for P-gp and MRP1, which are established cellular drug efflux transporters. The elimination rate of (99m)Tc… CONTINUE READING
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