Does the Agent of Scrapie Replicate without Nucleic Acid ?

@article{Alper1967DoesTA,
  title={Does the Agent of Scrapie Replicate without Nucleic Acid ?},
  author={Tikvah Alper and W. A. Cramp and D. A. Haig and M. C. Clarke},
  journal={Nature},
  year={1967},
  volume={214},
  pages={764-766}
}
Scrapie is a slowly developing disease of the nervous system. Experiments on the effects of ultra-violet irradiation of suspensions of infected mouse brain extracts confirm that the agent responsible for it does not depend on a nucleic acid for its ability to replicate. No evidence is obtained, however, to indicate whether the agent is associated with a protein. 
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