Does telomere elongation lead to a longer lifespan if cancer is considered?

Abstract

As ell proliferation is limited due to the loss of telomere repeats in DNA of normal somati ells during division, telomere attrition an possibly play an important role in determining the maximum life span of organisms as well as ontribute to the pro ess of biologi al ageing. With omputer simulations of ell ulture development in organisms, whi h onsist of tissues of normal somati ells with nite growth, we otain an in rease of life span and life expe tan y for longer telomeri DNA in the zygote. By additionally onsidering a two-mutation model for ar inogenesis and inde nite proliferation by the a tivation of telomerase, we demonstrate that the risk of dying due to an er an outweigh the positive e e t of longer telomeres on the longevity.

DOI: 10.1016/j.physa.2005.08.043

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@inproceedings{Masa2005DoesTE, title={Does telomere elongation lead to a longer lifespan if cancer is considered?}, author={Michael Masa and Stanislaw Cebrat and Dietrich Stauffer}, year={2005} }