Does stimulation of 5-HT1A receptors improve cognition in schizophrenia?

@article{Meltzer2008DoesSO,
  title={Does stimulation of 5-HT1A receptors improve cognition in schizophrenia?},
  author={Herbert Y. Meltzer and Tomiki Sumiyoshi},
  journal={Behavioural Brain Research},
  year={2008},
  volume={195},
  pages={98-102}
}

Improving cognition in schizophrenia with antipsychotics that elicit neurogenesis through 5-HT1A receptor activation

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The prefrontal cortex has been considered to regulate various aspects of cognitive abilities, e.g. working memory, memory organization, executive function, and attention, and findings from electrophysiological studies suggest these cognitive benefits of 5-HT1A agonism are mediated by glutamate (Glu) and γaminobutyric acid (GABA) neurons.

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This review concerns the role of 5-HT1A receptors in the modulation of nigrostriatal dopamine neurotransmission, with the aim of providing guidelines for future research to improve pharmacotherapy in schizophrenia and Parkinson's disease.

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  • Y. Ohno
  • Biology, Psychology
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  • 2010
New generation 5-HT(1A) ligands with greater potency, higher selectivity and improved pharmacokinetic properties are designed, which may overcome clinical efficacy limitations and/or improve adverse reactions in current CNS therapies.

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In agreement with pharmacological studies, presynaptic and postsynaptic 5- HT1A-R activation appears necessary for anxiolytic and antidepressant effects, respectively, yet, neurodevelopmental roles for 5-HT 1A-Rs are also involved.

Pharmacotherapy of cognition in schizophrenia

  • H. Meltzer
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  • 2015

Therapeutic Role of 5‐HT1A Receptors in The Treatment of Schizophrenia and Parkinson's Disease

  • Y. Ohno
  • Psychology, Medicine
    CNS neuroscience & therapeutics
  • 2011
Evidence that 5‐HT1A receptors seem to be a promising target for alleviating antipsychotic‐induced extrapyramidal side effects (EPS) and cognitive/affective disorders in schizophrenia and Parkinson's disease should encourage discovery of new 5‐ HT1A ligands, which can resolve the unmet clinical needs in the current therapy.
...

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