Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?

@article{Black1991DoesSI,
  title={Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?},
  author={Douglas L. Black},
  journal={Genes & development},
  year={1991},
  volume={5 3},
  pages={
          389-402
        }
}
  • Douglas L. Black
  • Published in Genes & development 1991
  • Biology, Medicine
  • The neuron-specific splicing of the mouse c-src N1 exon was analyzed. Model src genes, transiently expressed in HeLa and LA-N-5 neuroblastoma cells, were assayed for the insertion of the 18-nucleotide neuron-specific N1 exon into their product mRNA. The normal clone fails to use this exon in HeLa cells but inserts the exon into 50% of the mature mRNA in LA-N-5 cells. When the exon and flanking intron sequences are placed between two adenovirus exons, the N1 exon is still only inserted in the… CONTINUE READING

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