Does serotonin relax the rat anococcygeus muscle via 5-HT7 receptors?

@article{Emre2000DoesSR,
  title={Does serotonin relax the rat anococcygeus muscle via 5-HT7 receptors?},
  author={Selda Emre and S. Remzi Erdem and Meral Tuncer},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2000},
  volume={362},
  pages={96-100}
}
Abstract. The mechanisms of serotonin (5-HT)-induced contraction and relaxation were studied in the rat anococcygeus muscle. In the presence of prazosin (1 nM) and ketanserin (10 nM), concentration/response curves to 5-HT were shifted to the right and the maximum effects were not affected (pKB values 9.09±0.29 and 8.66±0.06 for prazosin and ketanserin, respectively). On contrary, guanethidine (10 µM) antagonised the 5-HT-induced contractions non-competitively. In the presence of guanethidine… 

Calcium-Antagonistic Activity of Sumatriptan in the Rat Anococcygeus Muscle

The results indicate that sumatriptan causes relaxation of the precontracted rat anococcygeus muscle by a calcium-antagonistic activity.

5‐Hydroxytryptamine is biotransformed by CYP2C9, 2C19 and 2B6 to hydroxylamine, which is converted into nitric oxide

In conclusion, CYP2B6, 2C9 and 2C19 biotransform 5‐HT, yielding hydroxylamine, which is converted to nitric oxide in the presence of catalase.

Modulation des cytochromes P450 par l'hypoxie : médiateurs et mécanismes d'action

The data indicate that serum from rabbits subjected to hypoxia contains mediators capable to modulate the activity and expression of cytochrome P450 isoforms, as well as for CYP3A6 up-regulation, which is proposed to contribute to nitric oxide formation.

Craniomandibular muscles, intraoral orthoses and migraine

  • E. Shevel
  • Medicine, Psychology
    Expert review of neurotherapeutics
  • 2005
Using the Migraine Specific Quality of Life Instrument (Version 2.1), it was found that the palatal nonoccluding splint significantly improved the quality of life of migraineurs.

References

SHOWING 1-10 OF 18 REFERENCES

Direct and indirect actions of 5-hydroxytryptamine in the rat anococcygeus muscle.

  • M. Oriowo
  • Biology
    Archives internationales de pharmacodynamie et de therapie
  • 1981
It is suggested that 5-hydroxytryptamine contracted the rat anococcygeus muscle directly (by activating tryptaminergic 'D' receptors) and indirectly by releasing noradrenaline at the nerve endings.

Pharmacological analysis of the postjunctional alpha-adrenoceptors of the rat anococcygeus muscle and vas deferens.

  • O. AdenekanF. Tayo
  • Biology, Medicine
    Archives internationales de pharmacodynamie et de therapie
  • 1985
A predominance ofalpha-1-adrenoceptors in the vas deferens located postjunctionally with a small population of alpha-2-subtype adrenocepters is suggested, whilst the anococcygeus muscle seems to contain relatively more alpha 2-adRenoceptor postJunctionally than the vasdeferens.

5-hydroxytryptamine and neurotransmitter release in canine blood vessels. Inhibition by low and augmentation by high concentrations.

  • M. McGrath
  • Biology, Chemistry
    Circulation research
  • 1977
Low concentrations of 5-HT depress sympathetic tone by inhibiting the release of transmitter during nerve depolarization through the cocaine-sensitive mechanism and therelease of norepinephrine.

Functional interaction between serotonin and other neuronal systems: focus on in vivo microdialysis studies.

Taking together, neurochemical approaches using microdialysis can contribute not only to clarification of the physiological role of the serotonergic neuronal systems but also might be a powerful pharmacological approach for the development of therapeutic strategies.

The rat anococcygeus muscle and its response to nerve stimulation and to some drugs

The inhibitory response to nerve stimulation is not mimicked by acetylcholine, isoprenaline or ATP, nor blocked by atropine, phentolamine, phenoxybenzamine, propranolol, hexamethonium or lysergic acid diethylamide.

Structure-activity study of some newly synthesized ergoline derivatives on 5-HT2 receptors and alpha-adrenoceptors in rabbit isolated aorta.

It is shown that relatively small modifications in the structure of the ergoline system led to pronounced changes in the affinity as well as intrinsic activity at both receptors studied, and LEK 8841 proved to be more selective for 5-HT2 receptors than ketanserin.

Pharmacological characterization of 5‐HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle

5‐HT induces relaxation of the canine rectum circular muscle through stimulation of a single population of smooth muscle 5‐HT4 receptors and for the first time, a non‐human species was shown to exhibit relaxant 5‐ HT4 receptors in the large intestine.

Evidence for multiple prejunctional receptor sites in rat isolated anococcygeus muscle.

  • A. RajaniO. Gulati
  • Biology, Chemistry
    Archives internationales de pharmacodynamie et de therapie
  • 1988
It is concluded that multiple prejunctional receptor activities for DA, ACh (muscarinic) and 5-HT, which modify the release of neurotransmitter, may be operative in this preparation.

Pharmacological evidence for the 5‐HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries

Data disclosing the involvement of the 5‐HT7 receptor in cerebrovascular relaxation may be strongly relevant in the light of: (1) the involvement in migraine; (2) the putative linkage between cephalovascular vasodilatation and migraine headache; and (3) the relatively high 5‐ HT7 receptor affinity of migraine prophylactic5‐HT antagonists.