Does secretin control insulin secretion?

  title={Does secretin control insulin secretion?},
  author={A. Greco and R. Manna and G. Ghirlanda and L. Altomonte and A. Bertoli},
  journal={Experimental and clinical endocrinology},
  volume={84 1},
The effect of secretin on insulin release has been studied in normal subjects after prestimulation with arginine. In order to make a comparison a pulse of glucose with arginine prestimulation was given. A pulse of 1 U/kg b.w. of secretin provokes a secretion of insulin that is weak and brief compared to that provoked by glucose; thus secretin fails to potentiate arginine-induced insulin secretion. Such a result does not support the hypothesis of secretin as the central hormone in the… Expand