Does reorganization in the cuneate nucleus following neonatal forelimb amputation influence development of anomalous circuits within the somatosensory cortex?

@article{Lane2008DoesRI,
  title={Does reorganization in the cuneate nucleus following neonatal forelimb amputation influence development of anomalous circuits within the somatosensory cortex?},
  author={Richard D. Lane and Charles P. Pluto and Cynthia L Kenmuir and Nicolas L Chiaia and Richard D. Mooney},
  journal={Journal of neurophysiology},
  year={2008},
  volume={99 2},
  pages={866-75}
}
Neonatal forelimb amputation in rats produces sprouting of sciatic nerve afferent fibers into the cuneate nucleus (CN) and results in 40% of individual CN neurons expressing both forelimb-stump and hindlimb receptive fields. The forelimb-stump region of primary somatosensory cortex (S-I) of these rats contains neurons in layer IV that express both stump and hindlimb receptive fields. However, the source of the aberrant input is the S-I hindlimb region conveyed to the S-I forelimb-stump region… CONTINUE READING

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