Does refining the phenotype improve replication rates? A review and replication of candidate gene studies on Major Depressive Disorder and Chronic Major Depressive Disorder.

@article{Luo2016DoesRT,
  title={Does refining the phenotype improve replication rates? A review and replication of candidate gene studies on Major Depressive Disorder and Chronic Major Depressive Disorder.},
  author={Xiaochen Luo and Nikolaos M. Stavrakakis and Brenda W Penninx and Fokko Jan Bosker and Willem A. Nolen and Dorret I. Boomsma and Eco J C de Geus and Johan H Smit and Harold Snieder and Ilja M. Nolte and Catharina A. Hartman},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2016},
  volume={171B 2},
  pages={
          215-36
        }
}
Replication has been poor for previously reported candidate genes involved in Major Depressive Disorder (MDD). One possible reason is phenotypic and genetic heterogeneity. The present study replicated genetic associations with MDD as defined in DSM-IV and with a more narrowly defined MDD subtype with a chronic and severe course. We first conducted a systematic review of genetic association studies on MDD published between September 2007 and June 2012 to identify all reported candidate genes… CONTINUE READING
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