Does reduced MHC diversity decrease viability of vertebrate populations?

@article{Radwan2010DoesRM,
  title={Does reduced MHC diversity decrease viability of vertebrate populations?},
  author={Jacek Radwan and Aleksandra Biedrzycka and Wiesław Babik},
  journal={Biological Conservation},
  year={2010},
  volume={143},
  pages={537 - 544}
}
  • Jacek Radwan, Aleksandra Biedrzycka, Wiesław Babik
  • Published in Biological conservation 2010
  • Biology, Medicine
  • Loss of genetic variation may render populations more vulnerable to pathogens due to inbreeding depression and depletion of variation in genes responsible for immunity against parasites. Here we review the evidence for the significance of variation in genes of the Major Histocompatibility Complex (MHC) for conservation efforts. MHC molecules present pathogen-derived antigens to the effector cells of the immune system and thus trigger the adaptive immune response. Some MHC genes are the most… CONTINUE READING

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