Does redox regulation of cell function explain why antioxidants perform so poorly as therapeutic agents?

@article{Gutteridge1999DoesRR,
  title={Does redox regulation of cell function explain why antioxidants perform so poorly as therapeutic agents?},
  author={John M C Gutteridge},
  journal={Redox report : communications in free radical research},
  year={1999},
  volume={4 3},
  pages={129-31}
}
In normal health, there is a balance between the formation of oxidising chemical species and their effective removal by protective antioxidants. Antioxidants are a diverse group of molecules with diverse functions. For example, they range from large highly specific proteinaceous molecules with catalytic properties to small lipid- and water-soluble molecules with non-specific scavenging or metal chelating properties. Antioxidants control the prevailing relationship between reducing or oxidising… CONTINUE READING