Does protein binding modulate the effect of angiotensin II receptor antagonists?

Abstract

Introduction Angiotensin II AT 1-receptor antagonists are highly bound to plasma proteins (≥ 99%). With some antagonists, such as DuP-532, the protein binding was such that no efficacy of the drug could be demonstrated clinically. Whether protein binding interferes with the efficacy of other antagonists is not known. We have therefore investigated in vitro… (More)
DOI: 10.1177/14703203010020010901

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