Does prorenin exert angiotensin-independent effects in vivo?


Thirteen years ago, Véniant et al1 made the intriguing observation that targeted expression of rat prorenin to the liver under the control of the human 1-antitrypsin promoter increased plasma prorenin levels 600-fold in male transgenic rats and caused cardiac hypertrophy, myocardial fibrosis, and severe renal lesions by 20 weeks of age. Renal renin content… (More)
DOI: 10.1161/HYPERTENSIONAHA.109.141069


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