Does prolonged β-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials

@inproceedings{Tamma2011DoesP,
  title={Does prolonged β-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials},
  author={Pranita D. Tamma and Nirupama Putcha and Yong Dal Suh and Kyle J Van Arendonk and Michael L Rinke},
  booktitle={BMC infectious diseases},
  year={2011}
}
BackgroundThe emergence of multi-drug resistant Gram-negatives (MDRGNs) coupled with an alarming scarcity of new antibiotics has forced the optimization of the therapeutic potential of available antibiotics. To exploit the time above the minimum inhibitory concentration mechanism of β-lactams, prolonging their infusion may improve outcomes. The primary objective of this meta-analysis was to determine if prolonged β-lactam infusion resulted in decreased mortality and improved clinical cure… CONTINUE READING
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