Does pretreatment testing for serotonin transporter polymorphisms lead to earlier effects of drug treatment in patients with major depression? A decision-analytic model.

@article{Smits2007DoesPT,
  title={Does pretreatment testing for serotonin transporter polymorphisms lead to earlier effects of drug treatment in patients with major depression? A decision-analytic model.},
  author={Kim M. Smits and Luc Jm Smits and Jan S. A. G. Schouten and Frenk Peeters and Martin H. Prins},
  journal={Clinical therapeutics},
  year={2007},
  volume={29 4},
  pages={691-702}
}
BACKGROUND An estimated 30% to 40% of patients with depression do not sufficiently respond to treatment with selective serotonin reuptake inhibitors (SSRIs) and the period in which treatment efficacy can be assessed is relatively long. Therefore, a test to identify potential nonresponders could be useful in the treatment of depression. Serotonin transporter gene (SLC6A4) variations have been reported to account for differences in the way individuals respond to SSRI treatment. OBJECTIVE A… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

A model to incorporate genetic testing (5-HTTLPR) in pharmacological treatment of major depressive disorders.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry • 2011
View 2 Excerpts
Highly Influenced

Pharmacogenetics of antidepressant response.

Journal of psychiatry & neuroscience : JPN • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…