Does physical activity increase or decrease the risk of sickle cell disease complications?

@article{Martin2015DoesPA,
  title={Does physical activity increase or decrease the risk of sickle cell disease complications?},
  author={Cyril Martin and Vincent Pialoux and Camille Faes and Emmanuelle Charrin and Sarah C. Skinner and Philippe Connes},
  journal={British Journal of Sports Medicine},
  year={2015},
  volume={52},
  pages={214 - 218}
}
Sickle cell disease (SCD) is the most common inherited disease in the world. Red blood cell sickling, blood cell-endothelium adhesion, blood rheology abnormalities, intravascular haemolysis, and increased oxidative stress and inflammation contribute to the pathophysiology of SCD. Because acute intense exercise may alter these pathophysiological mechanisms, physical activity is usually contra-indicated in patients with SCD. However, recent studies in sickle-cell trait carriers and in a SCD mice… 
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