Does physical activity increase or decrease the risk of sickle cell disease complications?

@article{Martin2015DoesPA,
  title={Does physical activity increase or decrease the risk of sickle cell disease complications?},
  author={Cyril Martin and V. Pialoux and Camille Faes and Emmanuelle Charrin and Sarah C. Skinner and P. Connes},
  journal={British Journal of Sports Medicine},
  year={2015},
  volume={52},
  pages={214 - 218}
}
Sickle cell disease (SCD) is the most common inherited disease in the world. Red blood cell sickling, blood cell-endothelium adhesion, blood rheology abnormalities, intravascular haemolysis, and increased oxidative stress and inflammation contribute to the pathophysiology of SCD. Because acute intense exercise may alter these pathophysiological mechanisms, physical activity is usually contra-indicated in patients with SCD. However, recent studies in sickle-cell trait carriers and in a SCD mice… Expand
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How Sickle Cell Disease Impairs Skeletal Muscle Function: Implications in Daily Life
TLDR
Although acute high-intensity exercise is not recommended forSCD patients because it may increase the risk of sickling, regular moderate-intensity physical activity could have beneficial effects on skeletal muscle and more generally on the well-being of SCD patients. Expand
Inflammation in sickle cell disease.
TLDR
The events that trigger inflammation in the disease, as well as the mechanisms, inflammatory molecules and cells that propagate these inflammatory processes are discussed. Expand
Moderate exercise training decreases inflammation in transgenic sickle cell mice.
TLDR
It is concluded that moderate intensity exercise training, without any noticeable complications, may be associated with limited baseline blood deoxygenation and inflammation in sickle cell mice, and reduce sequestration of sickle erythrocytes/congestion in the spleen. Expand
Sickle cell disease: A review
TLDR
The care of people with sickle cell disease may include infection prevention with vaccination and antibiotics, high fluid intake, folic acid supplementation, and pain medication, which may include blood transfusion and the medication hydroxycarbamide (hydroxyurea). Expand
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
TLDR
The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients. Expand
Micro- and macrovascular function in children with sickle cell anaemia and sickle cell haemoglobin C disease.
TLDR
Physical activity and fitness levels were markedly lower in sickle cell patients compared to healthy controls but no association was observed with vascular function. Expand
Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?
TLDR
Blood acidosis appears clearly to be a risk factor for HbS polymerization, red blood cell sickling and the occurrence of vaso‐occlusive crisis and could induce hyperkalaemia‐related complications. Expand
Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice.
TLDR
The main finding of the present study was that the exercise-induced intramuscular acidosis was systematically more pronounced in sickle cell disease (SCD) mice as compared with their control counterparts. Expand
Impaired muscle force production and higher fatigability in a mouse model of sickle cell disease.
TLDR
In vivo evidence of impaired muscle force production and resistance to fatigue in SCD is provided, independent of muscle mass, which is associated with muscle fatigability when exercise intensity is high. Expand
Exacerbated in vivo metabolic changes suggestive of a spontaneous muscular vaso-occlusive crisis in exercising muscle of a sickle cell mouse.
While sickle cell disease (SCD) is characterized by frequent vaso-occlusive crisis (VOC), no direct observation of such an event in skeletal muscle has been performed in vivo. The present study… Expand
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