Does physical activity increase or decrease the risk of sickle cell disease complications?

@article{Martin2015DoesPA,
  title={Does physical activity increase or decrease the risk of sickle cell disease complications?},
  author={Cyril Martin and Vincent Pialoux and Camille Faes and Emmanuelle Charrin and Sarah C. Skinner and Philippe Connes},
  journal={British Journal of Sports Medicine},
  year={2015},
  volume={52},
  pages={214 - 218}
}
Sickle cell disease (SCD) is the most common inherited disease in the world. Red blood cell sickling, blood cell-endothelium adhesion, blood rheology abnormalities, intravascular haemolysis, and increased oxidative stress and inflammation contribute to the pathophysiology of SCD. Because acute intense exercise may alter these pathophysiological mechanisms, physical activity is usually contra-indicated in patients with SCD. However, recent studies in sickle-cell trait carriers and in a SCD mice… 
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32 Citations

How Sickle Cell Disease Impairs Skeletal Muscle Function: Implications in Daily Life
TLDR
Although acute high-intensity exercise is not recommended forSCD patients because it may increase the risk of sickling, regular moderate-intensity physical activity could have beneficial effects on skeletal muscle and more generally on the well-being of SCD patients.
Inflammation in sickle cell disease.
TLDR
The events that trigger inflammation in the disease, as well as the mechanisms, inflammatory molecules and cells that propagate these inflammatory processes are discussed.
Moderate exercise training decreases inflammation in transgenic sickle cell mice.
Sickle cell disease: A review
TLDR
The care of people with sickle cell disease may include infection prevention with vaccination and antibiotics, high fluid intake, folic acid supplementation, and pain medication, which may include blood transfusion and the medication hydroxycarbamide (hydroxyurea).
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
TLDR
The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients.
Micro- and macrovascular function in children with sickle cell anaemia and sickle cell haemoglobin C disease.
Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?
TLDR
Blood acidosis appears clearly to be a risk factor for HbS polymerization, red blood cell sickling and the occurrence of vaso‐occlusive crisis and could induce hyperkalaemia‐related complications.
Exercise Capacity and Biomarkers Among Children and Adolescents With Sickle Cell Disease.
TLDR
The findings suggest increased baseline levels of biomarkers of hemolysis and inflammation impact on 6MWT performance, which is associated positively with age and inversely with reticulocyte count and interleukin 6.
Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice.
TLDR
The main finding of the present study was that the exercise-induced intramuscular acidosis was systematically more pronounced in sickle cell disease (SCD) mice as compared with their control counterparts.
Nutritional profile and its relationship with severity markers in adults with sickle cell anemia
TLDR
In light of the studied link between food intake and blood count, the importance of adequate nutritional support as part of the therapeutic management of individuals with SCA becomes evident, which impacts their prognosis.
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