Does perthionitrite (SSNO(-)) account for sustained bioactivity of NO? A (bio)chemical characterization.

  title={Does perthionitrite (SSNO(-)) account for sustained bioactivity of NO? A (bio)chemical characterization.},
  author={Rudolf Wedmann and A. Zahl and T. Shubina and M. D{\"u}rr and F. Heinemann and B. Bugenhagen and P. Burger and I. Ivanovi{\'c}-Burmazovi{\'c} and M. Filipovic},
  journal={Inorganic chemistry},
  volume={54 19},
  • Rudolf Wedmann, A. Zahl, +6 authors M. Filipovic
  • Published 2015
  • Chemistry, Medicine
  • Inorganic chemistry
  • Hydrogen sulfide (H2S) and nitric oxide (NO) are important signaling molecules that regulate several physiological functions. Understanding the chemistry behind their interplay is important for explaining these functions. The reaction of H2S with S-nitrosothiols to form the smallest S-nitrosothiol, thionitrous acid (HSNO), is one example of physiologically relevant cross-talk between H2S and nitrogen species. Perthionitrite (SSNO(-)) has recently been considered as an important biological… CONTINUE READING
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