Does paranode formation and maintenance require partitioning of neurofascin 155 into lipid rafts?

@article{Schafer2004DoesPF,
  title={Does paranode formation and maintenance require partitioning of neurofascin 155 into lipid rafts?},
  author={Dorothy P Schafer and Rashmi Bansal and Kristian L. Hedstrom and Steven E. Pfeiffer and Matthew N Rasband},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 13},
  pages={3176-85}
}
Paranodal axoglial junctions in myelinated nerve fibers are essential for efficient action potential conduction and ion channel clustering. We show here that, in the mature CNS, a fraction of the oligodendroglial 155 kDa isoform of neurofascin (NF-155), a major constituent of paranodal junctions, has key biochemical characteristics of a lipid raft-associated protein. However, despite its robust expression, NF-155 is detergent soluble before paranodes form and in purified oligodendrocyte cell… CONTINUE READING
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