Does oxidative stress participate in nerve cell death in Parkinson's disease?

@article{Hirsch1993DoesOS,
  title={Does oxidative stress participate in nerve cell death in Parkinson's disease?},
  author={Etienne C. Hirsch},
  journal={European neurology},
  year={1993},
  volume={33 Suppl 1},
  pages={52-9}
}
Parkinson's disease is characterized by a massive neuronal loss in several cell groups of the midbrain. However, the most consistent lesions are observed in dopaminergic systems including nigral neurons. Although the cause of this neuronal loss remains unknown, oxidative stress has been suspected to participate in the mechanism of nerve cell death for several reasons. (1) Lipid peroxidation, a consequence of oxygen free radical production, has been found to be elevated in the substantia nigra… CONTINUE READING
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