Does oxidative stress alter quadriceps endurance in chronic obstructive pulmonary disease?

  title={Does oxidative stress alter quadriceps endurance in chronic obstructive pulmonary disease?},
  author={Christelle Koechlin and Annabelle Couillard and David Simar and Jean-Paul Cristol and H{\'e}l{\`e}ne Bellet and Maurice Hayot and Christian G. Prefaut},
  journal={American journal of respiratory and critical care medicine},
  volume={169 9},
The role of exercise-induced oxidative stress in the reduced quadriceps endurance of chronic obstructive pulmonary disease (COPD) patients has never been shown. We conducted a randomized, double-blind, and crossover study in which nine severe patients performed localized dynamic quadriceps endurance tests at 40% of maximal strength after oral treatment with the antioxidant, N-acetylcysteine (NAC), and placebo. Venous blood was sampled before, immediately after exercise, and 6 hours later… CONTINUE READING


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