Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? A systematic review

@article{Keenan2004DoesNP,
  title={Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? A systematic review},
  author={Sean Keenan and Tasnim Sinuff and Deborah J. Cook and Nicholas S. Hill},
  journal={Critical Care Medicine},
  year={2004},
  volume={32},
  pages={2516-2523}
}
Context:The results of studies on noninvasive positive pressure ventilation (NPPV) for acute hypoxemic respiratory failure unrelated to cardiogenic pulmonary edema have been inconsistent. Objective:To assess the effect of NPPV on the rate of endotracheal intubation, intensive care unit and hospital length of stay, and mortality for patients with acute hypoxemic respiratory failure not due to cardiogenic pulmonary edema. Data Source:We searched the databases of MEDLINE (1980 to October 2003) and… 
Noninvasive Ventilation in Acute Hypoxemic Nonhypercapnic Respiratory Failure: A Systematic Review and Meta-Analysis
TLDR
There is no sufficient scientific evidence to recommend bilevel positive airway pressure or helmet due to the limited number of trials available, and large rigorous randomized trials are needed to answer these questions definitely.
Outcomes of noninvasive ventilation in acute hypoxemic respiratory failure in a respiratory intensive care unit in north India.
TLDR
NIV should be judiciously used in patients with AHRF, and a low baseline P(aO2)/F(IO2) ratio was associated with NIV failure.
Noninvasive positive pressure ventilation for patients with acute hypoxemic respiratory failure?
  • S. Keenan
  • Medicine
    Expert review of respiratory medicine
  • 2008
TLDR
There is a need for a large, multicenter, randomized, controlled trial to clarify whether NIV offers benefit in terms of a reduced need for endotracheal intubation, length of stay and hospital mortality.
High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis
TLDR
In patients with acute hypoxemic respiratory failure HFNC was not associated with a difference in mortality compared to NIV or standard oxygen, and there were no differences in pH, PaCO2, or rates of intubation or cardio-respiratory arrest.
Noninvasive positive-pressure ventilation as a weaning strategy for intubated adults with respiratory failure.
TLDR
Compared with IPPV weaning, NPPV weaned significantly decreased mortality, and the benefits for mortality were significantly greater in trials enrolling exclusively participants with COPD (risk ratio) and reintubation (RR 0.55) amidst significant heterogeneity.
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TLDR
A modest amount of favorable experimental evidence exists to support the use of CPAP in patients with cardiogenic pulmonary edema and data suggest a trend toward a decrease in mortality, although the potential for harm has not been excluded.
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TLDR
During acute respiratory failure due to cardiogenic pulmonary edema the early use of noninvasive pressure support ventilation accelerates the improvement in PaO2/FIO2, PaCO2, dyspnea, and respiratory rate, but does not affect the overall clinical outcome.
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TLDR
In a group of hemodynamically stable patients with severe ALI, NPPV had a high success rate and should be considered as a treatment option for patients in stable condition in the early phase of ALI/ARDS.
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Non-invasive positive pressure ventilation should be considered early in the course of respiratory failure and before severe acidosis ensues, to avoid the need for endotracheal intubation and reduce mortality in patients with COPD.
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TLDR
Despite early physiologic improvement, CPAP neither reduced the need for intubation nor improved outcomes in patients with acute hypoxemic, nonhypercapnic respiratory insufficiency primarily due to acute lung injury.
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The results of this prospective randomized study indicate that transplantation programs should consider NIV in the treatment of selected recipients of transplantation with acute respiratory failure.
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TLDR
The use of noninvasive ventilation prevented intubation, reduced the incidence of septic shock, and improved survival in patients with severe acute hypoxemic respiratory failure compared with high-concentration oxygen therapy.
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TLDR
In selected patients with ARF caused by severe CAP, NPPV was associated with a significant reduction in the rate of endotracheal intubation and duration of ICU stay, and a 2-mo survival advantage was seen in patients with COPD.
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TLDR
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Randomized, prospective trial of noninvasive positive pressure ventilation in acute respiratory failure.
TLDR
Noninvasive positive pressure ventilation administered by nasal or oronasal mask avoids the need for endotracheal intubation, rapidly improves vital signs, gas exchange, and sense of dyspnea, and may reduce mortality in selected patients with acute respiratory failure.
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