Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia?

@article{Iadecola1992DoesNO,
  title={Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia?},
  author={C Iadecola},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 9},
  pages={3913-6}
}
  • C Iadecola
  • Published 1992 in
    Proceedings of the National Academy of Sciences…
The endothelium-derived relaxing factor (EDRF), probably nitric oxide (NO) or a closely related compound (EDRF/NO), is a potent vasodilator that appears to regulate vascular tone in several vascular beds. I have investigated whether EDRF/NO is also involved in the regulation of the cerebral circulation--in particular, whether EDRF/NO participates in the increases in cerebral blood flow elicited by hypercapnia. Rats were anesthetized with halothane, 1-2% (vol/vol), paralyzed, and artificially… CONTINUE READING