Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM.

@article{Corbett1992DoesNO,
  title={Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM.},
  author={Jon Corbett and Michael L. McDaniel},
  journal={Diabetes},
  year={1992},
  volume={41 8},
  pages={897-903}
}
Cytokines have been implicated as immunological effector molecules that induce dysfunction and destruction of the pancreatic beta-cell. The mechanisms of cytokine action on the beta-cell are unknown; however, nitric oxide, resulting from cytokine-induced expression of nitric oxide synthase, has been implicated as the cellular effector molecule mediating beta-cell dysfunction. Nitric oxide is a free radical that targets intracellular iron-containing enzymes, which results in the loss of their… CONTINUE READING