Does metabolic failure at the synapse cause Alzheimer's disease?

Abstract

Alzheimer's disease (AD) a neurodegenerative disorder of widely distributed cortical networks evolves over years while A beta (Aβ) oligomer neurotoxicity occurs within seconds to minutes. This disparity combined with disappointing outcomes of anti-amyloid clinical trials challenges the centrality of Aβ as principal mediator of neurodegeneration… (More)
DOI: 10.1016/j.mehy.2014.10.013

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Cite this paper

@article{Engel2014DoesMF, title={Does metabolic failure at the synapse cause Alzheimer's disease?}, author={Peter A. Engel}, journal={Medical hypotheses}, year={2014}, volume={83 6}, pages={802-8} }