Does mechanical stimulation have any role in urinary bladder tissue engineering?

@article{Farhat2008DoesMS,
  title={Does mechanical stimulation have any role in urinary bladder tissue engineering?},
  author={W. Farhat and H. Yeger},
  journal={World Journal of Urology},
  year={2008},
  volume={26},
  pages={301-305}
}
IntroductionTissue engineering of the urinary bladder currently relies on biocompatible scaffolds that deliver biological and physical functionality with negligible risks of immunogenic or tumorigenic potential. Recent research suggests that autologous cells that are propagated in culture and seeded on scaffolds prior to implantation improve clinical outcomes. For example, normal urinary bladder development in utero requires regular filling and emptying, and current research suggests that… Expand
Construction and evaluation of urinary bladder bioreactor for urologic tissue-engineering purposes.
TLDR
Significantly greater UC growth occurred on the extracellular matrix scaffolds cultured in the bioreactor compared with conventional static laboratory conditions after 3 days of culture. Expand
Bladder biomechanics and the use of scaffolds for regenerative medicine in the urinary bladder
TLDR
Collection of comparable reference data from different animal models would be a helpful tool for researchers and will enable comparison of different scaffolds in order to optimize characteristics before entering preclinical and clinical trials. Expand
Bioengineering Approaches for Bladder Regeneration
TLDR
The purpose of this work is to review the state of the art of the current bioengineering advances and obstacles reported in bladder regeneration, emphasizing that still much more progress is required before bioengineered bladders become a commonplace in the clinical setting. Expand
The effect of a cyclic uniaxial strain on urinary bladder cells
TLDR
Mechanical stimuli did not enhance the proliferation and differentiation of urothelial cells and preconditioning may improve the functional in vivo outcome of smooth muscle cell seeded constructs for flexible organs such as the bladder. Expand
High-density collagen gel tubes as a matrix for primary human bladder smooth muscle cells.
TLDR
A method to produce tubular-shaped collagen scaffolds based on plastic compression produces a ready cell-seeded graft that does not need further in vitro culture prior to implantation, drastically shortening the production time of graft for urinary tract regeneration. Expand
Engineering functional bladder tissues
TLDR
The combination of smart scaffolds with controlled topography, the ability to deliver multiple trophic factors and an optimal cell source will allow for the engineering of functional bladder tissues in the near future. Expand
Tissue-Engineered Urinary Conduits
TLDR
The role of tissue engineering in the cystectomy population rests on the principle of sparing healthy intestinal tissue while replacing diseased bladder, and the neo-urinary conduit employs autologous fat smooth muscle cells which are seeded onto synthetic, biodegradable scaffolds. Expand
Urinary bladder and urethral tissue engineering, and 3D bioprinting approaches for urological reconstruction
In the last few decades, tissue engineering evolved as an exciting multidisciplinary field of research. The primary objective of this review is to critically analyze 3D bioprinting-based tissueExpand
Tissue engineering of human bladder.
  • A. Atala
  • Medicine
  • British medical bulletin
  • 2011
TLDR
Current research suggests that the use of biomaterial-based, bladder-shaped scaffolds seeded with autologous urothelial and smooth muscle cells is currently the best option for bladder tissue engineering. Expand
Urinary Tissue Engineering: Challenges and Opportunities.
TLDR
There is an immediate need for developing a functional TE-NUC that can improve the quality of life of patients with bladder cancer and major advancements and common challenges in constructing and regenerating a neo-urinary conduit are discussed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 38 REFERENCES
Feasibility study of a novel urinary bladder bioreactor.
TLDR
Preliminary results suggest that the bioreactor is a suitable model for simulating normal physiological conditions of bladder cycling in an ex vivo system. Expand
De novo reconstitution of a functional mammalian urinary bladder by tissue engineering
TLDR
This study demonstrates, for the first time, that successful reconstitution of an autonomous hollow organ is possible using tissue–engineering methods. Expand
Tissue engineering in urology: Where are we going?
TLDR
How these bioengineering techniques are applied to synthetic and natural scaffolds, such as polyglycolic acid and porcine small intestine submucosa, to increase bladder capacity, repair urethral strictures, and replace corporal plaques in Peyronie’s disease is investigated. Expand
Biaxial mechanical properties of muscle-derived cell seeded small intestinal submucosa for bladder wall reconstitution.
TLDR
Results suggest that MDC growth was supported by SIS and that initial remodeling of the SIS ECM had occurred within the first 10 days of incubation, but may have slowed once the MDC had grown to confluence within the S IS. Expand
New methods of bladder augmentation
TLDR
It is evident that urothelial‐urothelial anastomoses are preferable functionally for bladder augmentation, and experience is currently being gained with the recent clinical and experimental approaches to augmentation cystoplasty. Expand
Advanced bioreactor with controlled application of multi-dimensional strain for tissue engineering.
TLDR
A computer controlled bench-top bioreactor system with capability to apply complex concurrent mechanical strains to three-dimensional matrices independently housed in 24 reactor vessels, in conjunction with enhanced environmental and fluidic control is developed. Expand
A novel in-vitro system for the simultaneous exposure of bladder smooth muscle cells to mechanical strain and sustained hydrostatic pressure.
The novel hydrostrain system was designed in an effort to establish and maintain conditions that simulate the in-vivo mechanical environment of the bladder. In this laboratory system, ovine bladderExpand
Dynamic Mechanical Conditioning of Collagen-Gel Blood Vessel Constructs Induces Remodeling In Vitro
TLDR
It is concluded that dynamic mechanical conditioning during tissue culture leads to an improvement in the properties of tissue-engineered blood vessel constructs in terms of mechanical strength and histological organization. Expand
Effect of physical forces on bladder smooth muscle and urothelium.
TLDR
It is demonstrated that extracellular matrix synthesis by urothelial and smooth muscle cells can be modulated by stretch (strain) in the absence of neurological input. Expand
A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function.
TLDR
This model represents major progress in developing a biomimetic human urothelial culture model to explore molecular and functional relationships in normal and dysfunctional bladder physiology. Expand
...
1
2
3
4
...