Does long-term metformin treatment increase cardiac lipoprotein lipase?

  title={Does long-term metformin treatment increase cardiac lipoprotein lipase?},
  author={David Hauton},
  booktitle={Metabolism: clinical and experimental},
Acute activation of adenosine monophosphate-activated protein kinase (AMPK) or jumps in cardiac work increased cardiac endothelial lipoprotein lipase (LPL), yet it is unclear whether chronic AMPK activation maintains this elevated LPL. To activate AMPK chronically, metformin at low (300 mg/kg/d) and high dose (600 mg/kg/d) was administered in drinking water for 14 days. Control, metformin-treated, and 5-amino-imidazole-4-carboxamide riboside (AICAR)-treated (0.5 mmol/L) ex vivo hearts were… CONTINUE READING
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